Fabrication of multi-layered microparticle laden fixed hydrogel wound dressing via 3D printing for the treatment of thermal burns

Problem Statement

Currently, the gold standard of treatment for both partial thickness and full-thickness burns is autologous skin grafting after excision of burnt, necrotic or infected skin tissue. However, autologous skin grafting is limited by the area of uninjured skin available on the patient as a donor. Another source of skin cover to promote wound healing and skin growth is the use of allogeneic skin grafts which are both expensive and carry the risk of infection.

Objective

This project aims to develop a multi-layered wound dressing loaded with active therapeutic agents for the treatment of thermal burns to better complement current treatments for burns. The customized wound dressing could conform to the shape and size of the wound bed, provide customisable drug loading (personalised medicine) and drug release profiles that directly aids in wound healing.

An illustration of multi-layered hydrogel wound dressing 3D printing methodology being able to create hydrogel wound dressings with varying shapes and sizes.
An illustration of multi-layered hydrogel wound dressing 3D printing methodology being able to create hydrogel wound dressings with varying shapes and sizes.

Key Benefits/Outcomes

  • NUS successfully developed a workflow to fabricate wound dressing that is customisable with flexible drug loading and drug concentration.
  • NUS filed an SG provisional patent (Application No. 10202008411T) on the fabrication method of the novel hydrogel wound dressing.
  • Based on the result of an in-vivo animal test, the internal organ safety profile, haematological and biochemical test are comparable to control. The 3D printed wound dressing with an antibacterial drug also gives a better healing effect compared to conventional wound dressing film.
  • Moving forward, SGH will lead the communication with HSA and start the application of IRB for clinical translation.

Collaborator

Contacts

Mr. Marc Lee marc.lee@ntuitive.sg

Dr Ooi Thian Ngan ooi@nus.edu.sg